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In addition, it was demonstrated that glutathione depletion was one of the earliest oxidative signs detected in the course of PD, suggesting that oxidative damage occurs even before complex I deficiency 27

Monitoring and management of patients at a high risk for even mild persistent hypoglycaemia (7080 mg dl 1 ) may help to prevent skeletal complications due to loss of stable cBMAT and potentially also stable adipocyte-associated complications in other organ systems that remain to be identified (glands, joints, eyes and so on)